¿Notificación cuando cambia un archivo?

¿Existe algún mecanismo mediante el cual se me pueda notificar (en C #) cuando se modifica un archivo en el disco?

Ese sería System.IO.FileSystemWatcher .

Puedes usar la FileSystemWatcherclase.

public void CreateFileWatcher(string path)
{
    // Create a new FileSystemWatcher and set its properties.
    FileSystemWatcher watcher = new FileSystemWatcher();
    watcher.Path = path;
    /* Watch for changes in LastAccess and LastWrite times, and 
       the renaming of files or directories. */
    watcher.NotifyFilter = NotifyFilters.LastAccess | NotifyFilters.LastWrite 
       | NotifyFilters.FileName | NotifyFilters.DirectoryName;
    // Only watch text files.
    watcher.Filter = "*.txt";

    // Add event handlers.
    watcher.Changed += new FileSystemEventHandler(OnChanged);
    watcher.Created += new FileSystemEventHandler(OnChanged);
    watcher.Deleted += new FileSystemEventHandler(OnChanged);
    watcher.Renamed += new RenamedEventHandler(OnRenamed);

    // Begin watching.
    watcher.EnableRaisingEvents = true;
}

// Define the event handlers.
private static void OnChanged(object source, FileSystemEventArgs e)
{
    // Specify what is done when a file is changed, created, or deleted.
   Console.WriteLine("File: " +  e.FullPath + " " + e.ChangeType);
}

private static void OnRenamed(object source, RenamedEventArgs e)
{
    // Specify what is done when a file is renamed.
    Console.WriteLine("File: {0} renamed to {1}", e.OldFullPath, e.FullPath);
}

Utilice el FileSystemWatcher. Puede filtrar solo por eventos de modificación.