Hay varias formas de hacerlo:
Usando filter()( y operador)
query = meta.Session.query(User).filter(
User.firstname.like(search_var1),
User.lastname.like(search_var2)
)
Usando filter_by()( y operador)
query = meta.Session.query(User).filter_by(
firstname.like(search_var1),
lastname.like(search_var2)
)
Encadenamiento filter()o filter_by()( y operador)
query = meta.Session.query(User).\
filter_by(firstname.like(search_var1)).\
filter_by(lastname.like(search_var2))
El uso or_(), and_()ynot()
from sqlalchemy import and_, or_, not_
query = meta.Session.query(User).filter(
and_(
User.firstname.like(search_var1),
User.lastname.like(search_var2)
)
)